PRODUCTION OF N-OXIDES OF PYRIDYLACETYLENE AMINES OBTAINED FROM 2-METHYL-5-ETHYNYLPYRIDINE

Abduvakhab  Ikramov; Sevara Khоlikova

doi:10.56122/..v2i2 (26).420

Авторлор

Abduvakhab Ikramov Tashkent Institute of Chemical Technology
Sevara Khоlikova Tashkent State Technical University

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https://doi.org/10.56122/..v2i2%20(26).420

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2-methyl-5-ethynylpyridine, methylamine, ethylamine, piperidine, morpholine, catalyst, solvents, pyridylacetylene amine N-oxides.

Аннотация

This work reports the investigation of reactions between 2-methyl-5-ethynylpyridine N-oxide and a range of aliphatic and aromatic amines, leading to the formation of pyridylacetylene amine N-oxides. The synthesis route involved the dehydrogenation of 2-methyl-5-ethylpyridine to yield 2-methyl-5-vinylpyridine, followed by bromination and dehydrobromination to afford 2-methyl-5-ethynylpyridine. Its oxidation with perhydrol in acetic anhydride provided 2-methyl-5-ethynylpyridine N-oxide. Subsequently, the Mannich reaction was employed for the preparation of N-oxides of pyridylacetylene amines. The effects of solvents (methanol, ethanol, and n-dioxane), the use of a catalyst, and reaction time on product yields were systematically examined. The structural features and composition of the synthesized pyridylacetylene amine N-oxides were confirmed through IR and PMR spectroscopic analysis.

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